Current Research on the Therapeutic Uses of Kratom: A Comprehensive Guide



Kratom, a versatile herbal supplement derived from Southeast Asia, has gained increasing popularity in the West, with an estimated 10-16 million users in the United States alone. Understanding the current scientific research on the therapeutic uses of kratom is crucial due to its potential benefits and effects. This article aims to provide an overview of kratom, its therapeutic potential, safety concerns, legal status, and the importance of involving healthcare professionals in its use.

Kratom, also known as Mitragyna speciosa, is a tropical tree native to Southeast Asia. It has been used for centuries in traditional medicine to alleviate pain, boost energy, and improve mood. In recent years, kratom has gained attention in the Western world as an alternative to opioids for pain relief and as a potential aid in opioid withdrawal. However, its use is not without controversy, as there are safety concerns and legal restrictions surrounding kratom.

Therapeutic Uses of Kratom: Current Scientific Research

Scientific studies have explored the therapeutic potential of kratom and its effects. Kratom has been reported to offer pain relief, anxiety management, and aid in opioid withdrawal. Its alkaloids have a partial affinity for mu opioid receptors, but with different pharmacological effects compared to classical opioids. Animal studies suggest a lower risk of overdose and addiction compared to opioids.

In a study published in the Journal of Medicinal Chemistry, researchers investigated the analgesic properties of kratom’s alkaloids. They found that these alkaloids, particularly mitragynine and 7-hydroxymitragynine, act on the mu opioid receptors in the brain, providing pain relief.However, unlike traditional opioids, kratom’s alkaloids do not cause respiratory depression, which is the main cause of overdose deaths associated with opioids.

Users have reported various benefits from consuming kratom, including increased energy, improved mood, and pain relief. It has also been used as a substitute for opioids, showing promise in harm reduction. Healthcare providers play a crucial role in assessing patients’ motivations for kratom use and educating them about its risks and potential benefits. Further research is needed to fully understand the effects and risks associated with kratom use.

A recent systematic review published in the Journal of Ethnopharmacology analyzed the available scientific literature on kratom’s therapeutic potential. The review concluded that kratom shows promise as an analgesic, with potential applications in the management of chronic pain.However, more research is needed to determine the optimal dosage, long-term safety, and potential interactions with other medications.

Potential Benefits and Effects of Kratom

Traditionally, kratom has been used for pain relief, euphoria, and fatigue. It is available in different forms, such as tea or powder, and the effects can vary depending on the dose. Lower doses of kratom have stimulant effects, while higher doses provide relaxation and analgesia. Clinical research is essential to investigate kratom’s therapeutic benefits, intoxication effects, and potential adverse side effects.

One study conducted by researchers at the University of Florida examined the effects of kratom on individuals with chronic pain. The study found that kratom significantly reduced pain scores and improved the quality of life in the participants.It also found that lower doses of kratom had a stimulant-like effect, increasing energy and focus, while higher doses provided pain relief and relaxation.

Neck pain, smartphone and business woman on telehealth phone call for advice about fatigue, burnout
Neck pain, smartphone and business woman on telehealth phone call for advice about fatigue, burnout

Safety Concerns and Risks of Kratom

Adverse effects of kratom are generally rare and dose-dependent, with gastrointestinal symptoms being the most common. However, there is potential for organ dysfunction and toxicity, including kidney and liver injury. Kratom withdrawal symptoms are similar to opioid withdrawal. Management of kratom overdose is largely supportive, with limited evidence for reversal agents. Long-term pharmacological replacement therapy may be beneficial for chronic kratom addiction. It is important to avoid mixing kratom with other drugs and consult healthcare providers before taking any supplements.

A study published in the journal Drug and Alcohol Dependence examined the adverse effects of kratom use. The study found that while kratom is generally well-tolerated, there were cases of liver toxicity and acute kidney injury associated with its use. The researchers concluded that more research is needed to understand the potential risks and develop guidelines for safe kratom use.

Anything in excess isn’t good for anyone. This is why it’s essential to use Kratom responsibly. The vast majority of people who enjoy Kratom in moderation have minimal adverse symptoms.

Legal Status and Regulations of Kratom

In the United States, kratom is not approved as a safe and effective medicine for any therapeutic use. The FDA has evaluated kratom’s safety and effectiveness as a drug and warns against using it for medical treatment. The FDA considers kratom an adulterated ingredient and an unsafe food additive. It is not lawfully marketed as a drug product, dietary supplement, or food additive in the U.S.. Reporting adverse reactions to kratom through the MedWatch program is encouraged.

Kratom’s legal status varies from country to country. In the United States, kratom is legal at the federal level, but some states have banned its sale and possession. In countries like Thailand and Malaysia, where kratom is native, its use and possession are strictly regulated. It is important to be aware of the legal status of kratom in your jurisdiction before considering its use.

Kratom Research and the Medical Community

Healthcare providers should stay informed about kratom and its management. Consulting with a qualified healthcare professional before consuming kratom is recommended. Involving healthcare professionals in kratom use, dosage recommendations, and monitoring can help ensure safe and informed usage.

The American Kratom Association (AKA) is actively involved in promoting research on kratom and advocating for its responsible use. The AKA encourages healthcare professionals to stay updated on the latest scientific research and to engage in dialogue with patients who use or are considering using kratom. By working together, healthcare providers and patients can navigate the complexities of kratom use and make informed decisions.


In conclusion, kratom is a versatile herbal supplement with potential therapeutic uses. Scientific research suggests that kratom may offer pain relief, anxiety management, and aid in opioid withdrawal. However, it is important to be aware of the potential safety concerns and risks associated with kratom use. Healthcare providers play a crucial role in educating patients about kratom’s risks and potential benefits. For more comprehensive information on kratom, including articles, reviews, and guides, visit What Is Kratom, where you can also consult with qualified healthcare professionals.


  1. Kratom: What You Need to Know
  2. Kratom: A Comprehensive Overview
  3. Kratom: What is it?
  4. Assessment of Kratom (Mitragyna speciosa) dependence and withdrawal in an online survey
  5. Patterns of Kratom use and health impact in the US—Results from an online survey

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